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The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

8 Sept 2022

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis, including promoted migration and invasiveness, increased tumor stemness, and enhanced resistance to chemotherapy and immunotherapy. EMT is tightly regulated by...

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PMID: 36076302
DOI: 10.1186/s13045-022-01347-8

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