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Epithelial-mesenchymal transition orchestrates tumor microenvironment: current perceptions and challenges

2 Apr 2025

Abstract excerpt

The epithelial-mesenchymal transition (EMT) is a critical process in cancer progression, facilitating tumor cells to develop invasive traits and augmenting their migratory capabilities. EMT is primed by tumor microenvironment (TME)-derived signals, whereupon cancer cells undergoing EMT in turn remodel the TME, thereby modulating tumor progression and therapeutic response. This review discusses the mechanisms by...

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PMID: 40176117
DOI: 10.1186/s12967-025-06422-5

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