Article
No Causal Association between 25-Hydroxyvitamin D and Features of Skin Aging: Evidence from a Bidirectional Mendelian Randomization Study.
The Journal of investigative dermatology - 1 Nov 2017
Noordam Raymond, Hamer Merel A, Pardo Luba M, van der Nat Tamara, Kiefte-de Jong Jessica C, Kayser Manfred, Slagboom P Eline, Uitterlinden André, Zillikens M Carola, Beekman Marian, Nijsten Tamar, van Heemst Diana, Gunn David A
Abstract excerpt
Data from in vitro experiments suggest that vitamin D reduces the rate of skin aging, whereas population studies suggest the opposite, most likely due to confounding by UV exposure. We investigated whether there are causal associations between 25-hydroxyvitamin D concentrations and features of skin aging in a bidirectional Mendelian randomization study. In the Rotterdam Study (N = 3,831; 58.2% women, median age...
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