Article
Inclusion of Population-specific Reference Panel from India to the 1000 Genomes Phase 3 Panel Improves Imputation Accuracy.
Scientific reports - 27 Jul 2017
Ahmad Meraj, Sinha Anubhav, Ghosh Sreya, Kumar Vikrant, Davila Sonia, Yajnik Chittaranjan S, Chandak Giriraj R
Abstract excerpt
Imputation is a computational method based on the principle of haplotype sharing allowing enrichment of genome-wide association study datasets. It depends on the haplotype structure of the population and density of the genotype data. The 1000 Genomes Project led to the generation of imputation reference panels which have been used globally. However, recent studies have shown that population-specific panels...
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