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Article

Generation and characterization of interferon-lambda 1-resistant H1N1 influenza A viruses.

PloS one - 1 Jan 2017

Ilyushina Natalia A, Lugovtsev Vladimir Y, Samsonova Anastasia P, Sheikh Faruk G, Bovin Nicolai V, Donnelly Raymond P

Abstract excerpt

Influenza A viruses pose a constant potential threat to human health. In view of the innate antiviral activity of interferons (IFNs) and their potential use as anti-influenza agents, it is important to know whether viral resistance to these antiviral proteins can arise. To examine the likelihood of emergence of IFN-λ1-resistant H1N1 variants, we serially passaged the A/California/04/09 (H1N1) strain in a human...

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Source

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Identifiers

PMID: 28750037
DOI: 10.1371/journal.pone.0181999
PMCID: PMC5531537

Genes

IFNB1
IFNL1
IFNL2
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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