Article
Discovery of monoclonal antibodies cross-reactive to novel subserotypes of K. pneumoniae O3.
Scientific reports - 26 Jul 2017
Guachalla Luis M, Stojkovic Katarina, Hartl Katharina, Kaszowska Marta, Kumar Yadhu, Wahl Benjamin, Paprotka Tobias, Nagy Eszter, Lukasiewicz Jolanta, Nagy Gábor, Szijártó Valéria
Abstract excerpt
Klebsiella pneumoniae is responsible for nosocomial infections causing significant morbidity and mortality. Treatment of newly emerging multi-drug resistant strains is hampered due to severely limited antibiotic choices. Passive immunization targeting LPS O-antigens has been proposed as an alternative therapeutic option, given the limited variability of Klebsiella O-antigens. Here we report that the O3 serogroup,...
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