Article
Carbapenem-resistant Klebsiella pneumoniae exhibit variability in capsular polysaccharide and capsule associated virulence traits.
The Journal of infectious diseases - 1 Sept 2014
Diago-Navarro Elizabeth, Chen Liang, Passet Virginie, Burack Seth, Ulacia-Hernando Amaia, Kodiyanplakkal Rosy Priya, Levi Michael H, Brisse Sylvain, Kreiswirth Barry N, Fries Bettina C
Abstract excerpt
BACKGROUND: Novel therapies are urgently needed to treat carbapenem-resistant Klebsiella pneumoniae (CR-Kp)-mediated infection, which constitute a major health threat in the United States. In order to assess if it is feasible to develop anticapsular antibodies as a potential novel therapy, it is crucial to first systematically characterize capsular polysaccharide (CPS) and virulence traits in these strains....
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