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Article

Pigment epithelium-derived factor exerts opposite effects on endothelial cells of different phenotypes.

Biochemical and biophysical research communications - 21 Jun 2002

Hutchings Helen, Maitre-Boube Martine, Tombran-Tink Joyce, Plouët Jean

Abstract excerpt

The anti-angiogenic activity of pigment epithelium-derived factor (PEDF) has recently been discovered on the basis of its inhibition of ischemia-induced retinal neovascularization in an animal model of retinopathy of the premature. Moreover PEDF inhibits the migration and proliferation of various endothelial cells maintained in culture with FGF(2). Since vascular endothelial growth factor (VEGF) is the main...

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Identifiers

PMID: 12061772
DOI: 10.1016/S0006-291X(02)00548-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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