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Article

Natural Conformational Sampling of Human TNFα Visualized by Double Electron-Electron Resonance.

Biophysical journal - 25 Jul 2017

Carrington Bruce, Myers William K, Horanyi Peter, Calmiano Mark, Lawson Alastair D G

Abstract excerpt

Double electron-electron resonance in conjunction with site-directed spin labeling has been used to probe natural conformational sampling of the human tumor necrosis factor α trimer. We suggest a previously unreported, predeoligomerization conformation of the trimer that has been shown to be sampled at low frequency. A model of this trimeric state has been constructed based on crystal structures using the...

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Identifiers

PMID: 28746848
DOI: 10.1016/j.bpj.2017.06.007
PMCID: PMC5529296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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