Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.

doi:10.1128/JB.00166-10

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Article

Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.

Journal of bacteriology - 1 Jul 2010

Ioerger Thomas R, Feng Yicheng, Ganesula Krishna, Chen Xiaohua, Dobos Karen M, Fortune Sarah, Jacobs William R, Mizrahi Valerie, Parish Tanya, Rubin Eric, Sassetti Chris, Sacchettini James C

Abstract excerpt

The publication of the complete genome sequence for Mycobacterium tuberculosis H37Rv in 1998 has had a great impact on the research community. Nonetheless, it is suspected that genetic differences have arisen in stocks of H37Rv that are maintained in different laboratories. In order to assess the consistency of the genome sequences among H37Rv strains in use and the extent to which they have diverged from the...

Topics

Base Sequence
DNA, Bacterial
Genetic Variation
Genome, Bacterial
Laboratories
Mycobacterium tuberculosis
Phylogeny
Research

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Identifiers

PMID: 20472797
DOI: 10.1128/JB.00166-10
PMCID: PMC2897344

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