Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency.

Clinical genetics - 1 May 2016

Bouali N, Francou B, Bouligand J, Lakhal B, Malek I, Kammoun M, Warszawski J, Mougou S, Saad A, Guiochon-Mantel A

Abstract excerpt

Premature ovarian insufficiency (POI) affects approximately 1% of women before the age of 40. Genetic contribution is a significant component of POI. In this context, heterozygous mutations in NOBOX, BMP15 and GDF9 have been reported. The objective of our study was to evaluate the prevalence of these genes mutations in 125 unrelated Tunisian patients diagnosed with POI. The screening of NOBOX gene revealed three...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Mutation, Missense

Share to Prevalence

Share to Primary Ovarian Insufficiency

Share to Transcription Factors

Share to Tunisia

Source

Identifiers

PMID: 26848058
DOI: 10.1111/cge.12750

Genes

NOBOX
BMP15
GDF9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency.PMID 26848058Read ↗

Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort.Semantic proximity Read ↗

Next Generation Sequencing Should Be Proposed to Every Woman With “Idiopathic” Primary Ovarian InsufficiencySemantic proximity Read ↗

Selected Genetic Factors Associated with Primary Ovarian Insufficiency.Semantic proximity Read ↗

New NOBOX mutations identified in a large cohort of women with primary ovarian insufficiency decrease KIT-L expression.Semantic proximity Read ↗

NOBOX homeobox mutation causes premature ovarian failure.Semantic proximity Read ↗

Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variants.Semantic proximity Read ↗

Screening of premature ovarian insufficiency associated genes in Hungarian patients with next generation sequencing.Semantic proximity Read ↗

Mutational screening of SF1 and WNT4 in Tunisian women with premature ovarian failure.Semantic proximity Read ↗

Oocyte/zygote/embryo maturation arrest: a clinical study expanding the phenotype of NOBOX variants.Semantic proximity Read ↗

Compound heterozygous null mutations of NOBOX in sisters with delayed puberty and primary amenorrhea.Semantic proximity Read ↗

A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency.Semantic proximity Read ↗

"Evaluation of four genes associated with primary ovarian insufficiency in a cohort of Mexican women".Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.