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All-Cause Mortality and Cancer Risk Dependent on Blood Se Level and HRG rs10770 Genotypes on a Prospective Cohort of Women with Familial Breast Cancers.

International journal of molecular sciences - 5 Mar 2026

Lubiński Krzysztof, Stachowski Adam, Marciniak Wojciech, Derkacz Róża, Kiljańczyk Adam, Kiljańczyk Milena, Lener Marcin R, Pietrzak Sandra, Cybulski Cezary, Dębniak Tadeusz, Huzarski Tomasz, Kluźniak Wojciech, Sulikowski Tadeusz, Lubiński Jan, Scott Rodney J, Gronwald Jacek

Abstract excerpt

The aim of this study was to investigate whether genotypes of HRG may modify the effect of Se(selenium) on all-cause mortality and cancer risk. The study was conducted on 2782 initially unaffected women from families with familial breast cancers, all registered at the Hereditary Cancer Centre in Szczecin. Participants were aged 40 years or older and were recruited between September 2010 and March 2024. Women...

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Aged
Breast Neoplasms
BRCA1 gene
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 41828619
DOI: 10.3390/ijms27052402
PMCID: PMC12985312

Genes

HRG
BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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