Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial.

doi:10.1158/1078-0432.CCR-17-0381

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Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2017

Harttrampf Anne C, Lacroix Ludovic, Deloger Marc, Deschamps Frederic, Puget Stephanie, Auger Nathalie, Vielh Philippe, Varlet Pascale, Balogh Zsofia, Abbou Samuel, Allorant Adrien, Valteau-Couanet Dominique, Sarnacki Sabine, Gamiche-Rolland Louise, Meurice Guillaume, Minard-Colin Veronique, Grill Jacques, Brugieres Laurence, Dufour Christelle, Gaspar Nathalie, Michiels Stefan, Vassal Gilles, Soria Jean-Charles, Geoerger Birgit

Abstract excerpt

Purpose: This single-institutional feasibility study prospectively characterized genomic alterations in recurrent or refractory solid tumors of pediatric patients to select a targeted therapy.Experimental Design: Following treatment failure, patients with signed consent and ages above 6 months, underwent tumor biopsy or surgical resection of primary or metastatic tumor site. These newly acquired samples were...

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PMID: 28733441
DOI: 10.1158/1078-0432.CCR-17-0381

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