Proteasome Subunit Beta Type 1 P11A Polymorphism Is a New Prognostic Marker in Multiple Myeloma.

doi:10.1016/j.clml.2017.06.034

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Article

Proteasome Subunit Beta Type 1 P11A Polymorphism Is a New Prognostic Marker in Multiple Myeloma.

Clinical lymphoma, myeloma & leukemia - 1 Nov 2017

Varga Gergely, Mikala Gábor, Kiss Katalin Piroska, Kosóczki Éva, Szabó Edit, Meggyesi Nóra, Balassa Katalin, Kövy Petra, Tegze Bálint, Szombath Gergely, Tordai Attila, Andrikovics Hajnalka, Homolya László, Masszi Tamás

Abstract excerpt

BACKGROUND: Proteasome subunit beta type 1 (PSMB1) rs12717 polymorphism, a single nucleotide polymorphism with unknown functional effect, was recently reported to influence response to bortezomib-based therapy in follicular lymphoma. PATIENTS AND METHODS: We retrospectively analyzed the prognostic impact of this polymorphism in 211 consecutively diagnosed multiple myeloma cases, and performed in vitro experiments...

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PMID: 28733196
DOI: 10.1016/j.clml.2017.06.034

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PSMB1

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