Article
NFKB1 -94ins/delATTG polymorphism is a novel prognostic marker in first line-treated multiple myeloma.
British journal of haematology - 1 Mar 2015
Varga Gergely, Mikala Gábor, Andrikovics Hajnalka, Koszarska Magdalena, Balassa Katalin, Ádám Emma, Kozma András, Tordai Attila, Masszi Tamás
Abstract excerpt
Nuclear factor kappa B (NFKB) plays an important role in multiple myeloma (MM), and bortezomib affects this pathway. We retrospectively analysed the effect of the NFKB1 -94ins/delATTG polymorphism on the survival of 295 MM patients treated at a single centre. The median progression-free survival (PFS) was 790 (659-921) d in patients with NFKB1 homozygous insertion genotype (I/I, n = 99) and 624 (515-733) d in...
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