Article
Spectrum and functional validation of PSMB5 mutations in multiple myeloma.
Leukemia - 1 Feb 2019
Barrio Santiago, Stühmer Thorsten, Da-Viá Matteo, Barrio-Garcia Clara, Lehners Nicola, Besse Andrej, Cuenca Isabel, Garitano-Trojaola Andoni, Fink Severin, Leich Ellen, Chatterjee Manik, Driessen Christoph, Martinez-Lopez Joaquin, Rosenwald Andreas, Beckmann Roland, Bargou Ralf C, Braggio Esteban, Stewart A Keith, Raab Marc S, Einsele Hermann, Kortüm K Martin
Abstract excerpt
Despite an increasing number of approved therapies, multiple myeloma (MM) remains an incurable disease and only a small number of patients achieve prolonged disease control. Some genes have been linked with response to commonly used anti-MM compounds, including immunomodulators (IMiDs) and proteasome inhibitors (PIs). In this manuscript, we demonstrate an increased incidence of acquired proteasomal subunit...
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