Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone.

doi:10.1182/blood-2012-05-426924

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Article

Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone.

Blood - 29 Nov 2012

Lichter David I, Danaee Hadi, Pickard Michael D, Tayber Olga, Sintchak Michael, Shi Hongliang, Richardson Paul G, Cavenagh Jamie, Bladé Joan, Façon Thierry, Niesvizky Ruben, Alsina Melissa, Dalton William, Sonneveld Pieter, Lonial Sagar, van de Velde Helgi, Ricci Deborah, Esseltine Dixie-Lee, Trepicchio William L, Mulligan George, Anderson Kenneth C

Abstract excerpt

Variations within proteasome β (PSMB) genes, which encode the β subunits of the 20S proteasome, may affect proteasome function, assembly, and/or binding of proteasome inhibitors. To investigate the potential association between PSMB gene variants and treatment-emergent resistance to bortezomib and/or long-term outcomes, in the present study, PSMB gene sequence variation was characterized in tumor DNA samples from...

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Identifiers

PMID: 23018640
DOI: 10.1182/blood-2012-05-426924
PMCID: PMC3757460

Genes

PSMB5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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