IL-6 variant is associated with metastasis in breast cancer patients.

doi:10.1371/journal.pone.0181725

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Article

IL-6 variant is associated with metastasis in breast cancer patients.

PloS one - 1 Jan 2017

Abana Chike O, Bingham Brian S, Cho Ju Hwan, Graves Amy J, Koyama Tatsuki, Pilarski Robert T, Chakravarthy A Bapsi, Xia Fen

Abstract excerpt

INTRODUCTION: Although tumor metastases remain significant drivers of mortality, the genetic factors that increase the risks of metastases are not fully identified. Interleukin 6 (IL-6) has emerged as an important factor in breast cancer progression with IL-6 single nucleotide polymorphism (SNP) variants shown to affect survival. We hypothesized that SNPs of the IL-6 promoter at rs1800795 in breast cancer...

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PMID: 28732081
DOI: 10.1371/journal.pone.0181725
PMCID: PMC5521838

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