Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of CDKN1C in a Recurrent Atypical Teratoid/Rhabdoid Tumor.

Journal of pediatric hematology/oncology - 1 Nov 2017

Tran Dustin, Camelo-Piragua Sandra, Gupta Avneesh, Gowans Kate, Robertson Patricia L, Mody Rajen, Koschmann Carl

Abstract excerpt

Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant tumor that is commonly associated with biallelic alterations of SMARCB1. Recurrent or refractory AT/RT has not been molecularly characterized as well. We present the case of a child with recurrent AT/RT who underwent clinically integrated molecular profiling (germline DNA and tumor DNA/RNA sequencing). This demonstrated a somatic lesion in CDKN1C alongside...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Combined Modality Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p57

Share to Immunohistochemistry

Share to Magnetic Resonance Imaging

Share to Recurrence

Share to Rhabdoid Tumor

Share to Teratoma

Source

Open in PubMed Open full text

Identifiers

PMID: 28731921
DOI: 10.1097/MPH.0000000000000873
PMCID: PMC5656519

Genes

SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of CDKN1C in a Recurrent Atypical Teratoid/Rhabdoid Tumor.PMID 28731921Read ↗

Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomicsSemantic proximity Read ↗

Advancing biology-based therapeutic approaches for atypical teratoid rhabdoid tumorsSemantic proximity Read ↗

High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors.Semantic proximity Read ↗

SMARCB1-deficient and SMARCA4-deficient Malignant Brain Tumors With Complex Copy Number Alterations and TP53 Mutations May Represent the First Clinical Manifestation of Li-Fraumeni Syndrome.Semantic proximity Read ↗

Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases.Semantic proximity Read ↗

SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis.Semantic proximity Read ↗

Atypical Teratoid Rhabdoid Tumour : From Tumours to TherapiesSemantic proximity Read ↗

Molecular genetics of atypical teratoid/rhabdoid tumor.Semantic proximity Read ↗

Description of a new oncogenic mechanism for atypical teratoid rhabdoid tumors in patients with ring chromosome 22.Semantic proximity Read ↗

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes.Semantic proximity Read ↗

Development and epigenetic regulation of Atypical teratoid/rhabdoid tumors in the context of cell-of-origin and halted cell differentiationSemantic proximity Read ↗

Clinicopathologic comparison of familial versus sporadic atypical teratoid/rhabdoid tumors (AT/RT) of the central nervous system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.