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Article

Functional variation of SHP-2 promoter is associated with preterm birth and delayed myelination and motor development in preterm infants.

Scientific reports - 20 Jul 2017

Shim So-Yeon, Jeong Hye Jin, Park Hyo Jin, Kwon Eun Young, Kim Bo Min, Choi Yang Ji, Choi Youn-Hee, Cho Su Jin, Choi Ji Ha, Park Eun Ae

Abstract excerpt

Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP-2) is a cytoplasmic tyrosine phosphatase that is highly expressed in hematopoietic cells and in the CNS and exerts opposite effects on signal transduction by exerting a neuroprotective or proapoptotic effect. Several mutations of SHP-2 have been found in children with myeloproliferative disorders or malignant leukemia, and some of these can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28729690
DOI: 10.1038/s41598-017-06401-x
PMCID: PMC5519743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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