Article
Isosorbide-based peptidomimetics as inhibitors of hepatitis C virus serine protease.
Bioorganic & medicinal chemistry letters - 15 Aug 2017
Portela Aline C, Barros Thalita G, Lima Camilo H da S, Dias Luiza R S, Azevedo Pedro H R de A, Dantas Anna Sophia C L, Mohana-Borges Ronaldo, Ventura Gustavo T, Pinheiro Sergio, Muri Estela M F
Abstract excerpt
Hepatitis C infection is a cause of chronic liver diseases such as cirrhosis and carcinoma. The current therapy for hepatitis C has limited efficacy and low tolerance. The HCV encodes a serine protease which is critical for viral replication, and few protease inhibitors are currently on the market. In this paper, we describe the synthesis and screening of novel isosorbide-based peptidomimetic inhibitors, in which...
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