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Article

Computational study on the drug resistance mechanism of HCV NS3 protease to BMS-605339.

Biotechnology and applied biochemistry - 1 Mar 2017

Wang Huiqun, Guo Chenchen, Chen Bo-Zhen, Ji Mingjuan

Abstract excerpt

NS3 protease plays a vital role in the replication of the hepatitis C virus (HCV). BMS-605339 is a novel linear tetra-peptide α-ketoamide inhibitor of NS3 protease and shows specificity for HCV NS3 protease genotype 1a and genotype 1b. Mutation at the key site 168 of the HCV NS3 protease can induce resistance to BMS-605339, which greatly affects the antiviral therapy efficacy to hepatitis C. In the present study,...

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Source

Identifiers

PMID: 26790544
DOI: 10.1002/bab.1479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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