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Article

Discovery of a Silicon-Containing Pan-Genotype Hepatitis C Virus NS5A Inhibitor.

Journal of medicinal chemistry - 28 May 2020

Liu Baomin, Gai Kuo, Qin Hui, Wang Jie, Liu Xushi, Cao Yuan, Lu Qin, Lu Dandan, Chen Deyang, Shen Hengqiao, Song Wei, Mei Jia, Wang Xiaojin, Xu Hongjiang, Zhang Yinsheng

Abstract excerpt

We describe a study leading to the discovery of compound 11, a pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with excellent potency, metabolic stability, and pharmacokinetics (PK). Compound 11 incorporating a 4-silapiperidine group was discovered by further optimizing our previous lead with a triethylsilyl moiety. It displayed great potency against genotype 1 subtype a (GT1a),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32293179
DOI: 10.1021/acs.jmedchem.0c00082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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