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Article

Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2017

Karasik David, Demissie Serkalem, Lu Darlene, Broe Kerry E, Boyd Steven K, Liu Ching-Ti, Hsu Yi-Hsiang, Bouxsein Mary L, Kiel Douglas P

Abstract excerpt

Genetic factors contribute to the risk of bone fractures, partly because of effects on bone strength. High-resolution peripheral quantitative computed tomography (HR-pQCT) estimates bone strength using micro-finite element analysis (µFEA). The goal of this study was to investigate if the bone failure load estimated by HR-pQCT-based µFEA is heritable and to what extent it shares genetic regulation with areal bone...

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Identifiers

PMID: 28722129
DOI: 10.1002/jbmr.3200
PMCID: PMC5685872

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