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Article

Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish.

Development (Cambridge, England) - 15 Jul 2017

Dimri Manali, Bilogan Cassandra, Pierce Lain X, Naegele Gregory, Vasanji Amit, Gibson Isabel, McClendon Allyson, Tae Kevin, Sakaguchi Takuya F

Abstract excerpt

The intrahepatic biliary network is a highly branched three-dimensional network lined by biliary epithelial cells, but how its branching patterns are precisely established is not clear. We designed a new computer-based algorithm that quantitatively computes the structural differences of the three-dimensional networks. Utilizing the algorithm, we showed that inhibition of Cyclin-dependent kinase 5 (Cdk5) led to...

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Share to Actin Depolymerizing Factors
Share to Bile Ducts, Intrahepatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 5

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Share to Imaging, Three-Dimensional

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Source

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Identifiers

PMID: 28720653
DOI: 10.1242/dev.147397
PMCID: PMC5536925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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