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Article

Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors.

Diabetes - 1 Jan 2018

Liu Ka-Cheuk, Leuckx Gunter, Sakano Daisuke, Seymour Philip A, Mattsson Charlotte L, Rautio Linn, Staels Willem, Verdonck Yannick, Serup Palle, Kume Shoen, Heimberg Harry, Andersson Olov

Abstract excerpt

Inhibition of notch signaling is known to induce differentiation of endocrine cells in zebrafish and mouse. After performing an unbiased in vivo screen of ∼2,200 small molecules in zebrafish, we identified an inhibitor of Cdk5 (roscovitine), which potentiated the formation of β-cells along the intrapancreatic duct during concurrent inhibition of notch signaling. We confirmed and characterized the effect with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28986398
DOI: 10.2337/db16-1587
PMCID: PMC6463766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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