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Article

Protective role of antioxidant compounds against peroxynitrite-mediated modification of R54C mutant αA-crystallin.

Archives of biochemistry and biophysics - 1 Sept 2017

Khoshaman Kazem, Yousefi Reza, Moosavi-Movahedi Ali Akbar

Abstract excerpt

As a highly potent reactive oxygen and nitrogen species, peroxynitrite (PON) has endogenous production in the eye ball and contributes to a variety of ocular disorders. In the current study the structural characteristics, chaperone-like activity and conformational stability of R54C mutant αA-crystallin (αA-Cry) were studied upon modification with PON and in the presence of three antioxidant compounds such as...

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PMID: 28720375
DOI: 10.1016/j.abb.2017.07.007

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