Article
Copy number variations of the IL-22 gene are associated with ankylosing spondylitis: A case-control study in Chinese Han population.
Human immunology - 1 Sept 2017
Zhang Xu, Li Xiaona, Han Renfang, Chen Mengya, Yuan Yaping, Hu Xingxing, Wang Mengmeng, Li Rui, Yang Xiao, Xia Qing, Ma Yubo, Yang Jiajia, Tong Jingjing, Xu Shengqian, Xu Jianhua, Shuai Zongwen, Pan Faming
Abstract excerpt
IL-22 provides a new insight into the mechanisms of autoimmunity, and copy number variations (CNVs) are associated with autoimmune diseases. This study aims to explore the association of IL-22 gene CNVs with ankylosing spondylitis (AS) susceptibility. The copy numbers of IL-22 gene (2 fragments: IL-22_1, IL-22_2) were examined by AccuCopy™ methods in a cohort of 649 AS patients and 628 controls. Association of...
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