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Article

Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish

14 May 2010

Abstract excerpt

OBJECTIVE: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development. METHODS AND RESULTS: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch...

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PMID: 20466977
DOI: 10.1161/atvbaha.110.203034

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