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Article

Tid1-S regulates the mitochondrial localization of EGFR in non-small cell lung carcinoma

17 Jul 2017

Abstract excerpt

The epidermal growth factor receptor (EGFR) is the major driver of non-small cell lung carcinoma (NSCLC). Mitochondrial accumulation of EGFR has been shown to promote metastasis in NSCLC, yet little is known about how the mitochondrial localization of EGFR is regulated. In this work, we show that Tid1 (also known as mitochondrial HSP40) is involved in the mitochondrial localization of EGFR, and that the DnaJ...

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PMID: 28714950
DOI: 10.1038/oncsis.2017.62

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