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Article

Role of protein degradation systems in colorectal cancer

14 Mar 2024

Abstract excerpt

Protein degradation is essential for maintaining protein homeostasis. The ubiquitin‒proteasome system (UPS) and autophagy-lysosome system are the two primary pathways responsible for protein degradation and directly related to cell survival. In malignant tumors, the UPS plays a critical role in managing the excessive protein load caused by cancer cells hyperproliferation. In this review, we provide a...

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PMID: 38485957
DOI: 10.1038/s41420-023-01781-8

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