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Article

The mechanism of resistance to favipiravir in influenza

23 Oct 2018

Abstract excerpt

Favipiravir is a broad-spectrum antiviral that has shown promise in treatment of influenza virus infections. While emergence of resistance has been observed for many antiinfluenza drugs, to date, clinical trials and laboratory studies of favipiravir have not yielded resistant viruses. Here we show evolution of resistance to favipiravir in the pandemic H1N1 influenza A virus in a laboratory setting. We found that...

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PMID: 30352857
DOI: 10.1073/pnas.1811345115

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