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Article

Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.

The Journal of biological chemistry - 18 Aug 2017

Upadhyay Arunkumar S, Stehling Oliver, Panayiotou Christakis, Rösser Ralf, Lill Roland, Överby Anna K

Abstract excerpt

Viperin (RSAD2) is an interferon-stimulated antiviral protein that belongs to the radical S-adenosylmethionine (SAM) enzyme family. Viperin's iron-sulfur (Fe/S) cluster is critical for its antiviral activity against many different viruses. CIA1 (CIAO1), an essential component of the cytosolic iron-sulfur protein assembly (CIA) machinery, is crucial for Fe/S cluster insertion into viperin and hence for viperin's...

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Source

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Identifiers

PMID: 28615450
DOI: 10.1074/jbc.M117.780122
PMCID: PMC5566539

Genes

MMS19
CIAO1
RSAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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