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Article

Structural Basis of the Substrate Selectivity of Viperin.

Biochemistry - 11 Feb 2020

Fenwick Michael K, Su Dan, Dong Min, Lin Hening, Ealick Steven E

Abstract excerpt

Viperin is a radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication by converting cytidine triphosphate (CTP) into 3'-deoxy-3',4'-didehydro-CTP and by additional undefined mechanisms operating through its N- and C-terminal domains. Here, we describe crystal structures of viperin bound to a SAM analogue and CTP or uridine triphosphate (UTP) and report kinetic parameters for viperin-catalyzed...

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Identifiers

PMID: 31917549
DOI: 10.1021/acs.biochem.9b00741
PMCID: PMC7920147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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