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Article

Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?

The Journal of biological chemistry - 23 Dec 2016

Makins Caitlyn, Ghosh Soumi, Román-Meléndez Gabriel D, Malec Paige A, Kennedy Robert T, Marsh E Neil G

Abstract excerpt

Viperin is an endoplasmic reticulum-associated antiviral responsive protein that is highly up-regulated in eukaryotic cells upon viral infection through both interferon-dependent and independent pathways. Viperin is predicted to be a radical S-adenosyl-l-methionine (SAM) enzyme, but it is unknown whether viperin actually exploits radical SAM chemistry to exert its antiviral activity. We have investigated the...

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PMID: 27834682
DOI: 10.1074/jbc.M116.751040
PMCID: PMC5207188

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Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?PMID 27834682Read ↗

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