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Mammalian Host-Versus-Phage immune response determines phage fate in vivo

6 Oct 2015

Abstract excerpt

Emerging bacterial antibiotic resistance draws attention to bacteriophages as a therapeutic alternative to treat bacterial infection. Examples of phage that combat bacteria abound. However, despite careful testing of antibacterial activity in vitro, failures nevertheless commonly occur. We investigated immunological response of phage antibacterial potency in vivo. Anti-phage activity of phagocytes, antibodies,...

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PMID: 26440922
DOI: 10.1038/srep14802

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