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Article

Genetic variants underlying vitamin D metabolism and VDR-TGFβ-1-SMAD3 interaction may impact on HCV progression: a study based on dbGaP data from the HALT-C study.

Journal of human genetics - 1 Nov 2017

de Azevedo Laura A, Matte Ursula, da Silveira Themis R, Álvares-da-Silva Mário R

Abstract excerpt

Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFβ-1/SMAD3 effect mediated by the vitamin D receptor. Thus, we hypothesized that genetic variants involved in vitamin D metabolism and/or VDR/TGFβ-1/SMAD3 interaction could impact on the progression of chronic HCV. We obtained or imputed genotypes for 40 single nucleotide polymorphisms...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Hepatocellular
Share to Hepacivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Liver Neoplasms

Share to Receptors, Calcitriol

Share to Smad3 Protein

Share to Transforming Growth Factor beta1

Share to Vitamin D

Source

Identifiers

PMID: 28703134
DOI: 10.1038/jhg.2017.75

Genes

SMAD3
VDR
TGFB1
DHCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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