Article
Mitochondrial decay in aging.
Biochimica et biophysica acta - 24 May 1995
Ames B N, Shigenaga M K, Hagen T M
Abstract excerpt
Several mitochondrial functions decline with age. The contributing factors include, the intrinsic rate of proton leakage across the inner mitochondrial membrane (a correlate of oxidant formation), decreased membrane fluidity, and decreased levels and function of cardiolipin, which supports the fu...
Topics
- Aging
- Animals
- Brain
- DNA Damage
- DNA, Mitochondrial
- Humans
- Lipid Metabolism
- Liver
- Male
- Mitochondria
- Mitochondria, Liver
- Mutation
- Proteins
- Rats
- Rats, Inbred F344