Article
Telomere length and somatic mutations in correlation with response to immunosuppressive treatment in aplastic anaemia.
British journal of haematology - 1 Aug 2017
Park Hee S, Park Si N, Im Kyongok, Kim Sung-Min, Kim Jung-Ah, Hwang Sang M, Lee Dong S
Abstract excerpt
We investigated the frequencies of cytogenetic aberrations and somatic mutations of prognostic relevance in 393 patients with aplastic anaemia (AA). Clonality was determined by G-banding/fluorescence in situ hybridization (FISH) (n = 245), and targeted capture sequencing was performed for 88 haematopoiesis-related genes (n = 70). The telomere length (TL) of bone marrow nucleated cells was measured at the single...
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