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Novel mutations in the exon 5, intron 2 and 3' UTR regions of IL-12B gene were observed in clinically proven tuberculosis patients of south India.

Cytokine - 1 Nov 2017

Babu Pallipamu Prakash, Kumar Pasupuleti Santhosh, Mohan Alladi, Kumar Bhattaram Siddhartha, Sarma Potukuchi Venkata Gurunadha Krishna

Abstract excerpt

Interleukin-12 (IL-12) is formed by the interaction of IL-12p35 and IL-12p40 expressed independently from IL-12A and IL-12B genes. This interleukin plays prominent role in the T-helper type-1 (Th1) response against intracellular pathogens. Variations in IL-12B gene causes disruption of various activities one of them is suppression of Th1 response and is one of the characteristic features observed in patients with...

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PMID: 28697396
DOI: 10.1016/j.cyto.2017.07.003

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