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Article

Computational characterization of the substrate-binding mode in coproporphyrinogen III oxidase.

The journal of physical chemistry. B - 3 Mar 2011

Silva Pedro J, Ramos Maria João

Abstract excerpt

Oxygen-dependent coproporphyrinogen III oxidase catalyzes the sequential decarboxylation of the propionate substituents present on the A and B rings of coproporphyrinogen III in the heme biosynthetic pathway. Although extensive experimental investigation of this enzyme has already afforded many insights into its reaction mechanism, several key features (such as the substrate binding mode, the characterization of...

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Identifiers

PMID: 21291195
DOI: 10.1021/jp110289d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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