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Article

Genetics and clinical response to warfarin and edoxaban in patients with venous thromboembolism.

Heart (British Cardiac Society) - 1 Nov 2017

Vandell Alexander G, Walker Joseph, Brown Karen S, Zhang George, Lin Min, Grosso Michael A, Mercuri Michele F

Abstract excerpt

OBJECTIVE: The aim of this study was to investigate whether genetic variants can identify patients with venous thromboembolism (VTE) at an increased risk of bleeding with warfarin. METHODS: Hokusai-venous thromboembolism (Hokusai VTE), a randomised, multinational, double-blind, non-inferiority trial, evaluated the safety and efficacy of edoxaban versus warfarin in patients with VTE initially treated with heparin....

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Source

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Identifiers

PMID: 28689179
DOI: 10.1136/heartjnl-2016-310901
PMCID: PMC5749368

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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