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Processing and Subcellular Localization of the Hepatitis E Virus Replicase: Identification of Candidate Viral Factories

24 Feb 2022

Abstract excerpt

Hepatitis E virus (HEV) is the major cause of acute hepatitis worldwide. HEV is a positive-sense RNA virus expressing three open reading frames (ORFs). ORF1 encodes the ORF1 non–structural polyprotein, the viral replicase which transcribes the full-length genome and a subgenomic RNA that encodes the structural ORF2 and ORF3 proteins. The present study is focused on the replication step with the aim to determine...

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PMID: 35283856
DOI: 10.3389/fmicb.2022.828636

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