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Article

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

6 Jul 2017

Abstract excerpt

Abstract The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated. In addition, the role of the bone marrow stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly understood. In this study, we conducted a DNA methylome analysis of bone marrow–derived stromal cells from myelodysplastic syndrome (MDS)...

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PMID: 28684528
DOI: 10.1158/0008-5472.can-17-0282

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