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Negri bodies are viral factories with properties of liquid organelles

28 Jun 2017

Abstract excerpt

Replication of Mononegavirales occurs in viral factories which form inclusions in the host-cell cytoplasm. For rabies virus, those inclusions are called Negri bodies (NBs). We report that NBs have characteristics similar to those of liquid organelles: they are spherical, they fuse to form larger structures, and they disappear upon hypotonic shock. Their liquid phase is confirmed by FRAP experiments. Live-cell...

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PMID: 28680096
DOI: 10.1038/s41467-017-00102-9

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