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Structural and molecular properties of mumps virus inclusion bodies

6 Dec 2024

Abstract excerpt

Viral RNA synthesis of mononegaviruses occurs in cytoplasmic membraneless organelles called inclusion bodies (IBs). Here, we report that IBs of mumps virus (MuV), which is the causative agent of mumps and belongs to the family Paramyxoviridae , displayed liquid organelle properties formed by liquid-liquid phase separation. Super-resolution microscopic analysis of MuV IBs demonstrated that nucleocapsid and phospho...

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PMID: 39642233
DOI: 10.1126/sciadv.adr0359

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