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Liquid-liquid phase separation is essential for reovirus viroplasm formation and immune evasion

28 Aug 2024

Abstract excerpt

family are known to replicate and assemble in cytoplasmic inclusion bodies termed viroplasms; however, the detailed mechanism underlying GCRV viroplasm formation and its specific roles in virus infection remains largely unknown. Here, we demonstrate that GCRV viroplasms form through liquid-liquid phase separation (LLPS) of the nonstructural protein NS80 and elucidate the specific role of LLPS during reovirus...

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PMID: 39194247
DOI: 10.1128/jvi.01028-24

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