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Article

Maternal placenta modulates a deleterious fetal mutation.

Biology of reproduction - 1 Aug 2017

Xu Hongen, Pausch Hubert, Venhoranta Heli, Rutkowska Karolina, Wurmser Christine, Rieblinger Beate, Flisikowska Tatiana, Frishman Dmitrij, Zwierzchowski Lech, Fries Ruedi, Andersson Magnus, Kind Alexander, Schnieke Angelika, Flisikowski Krzysztof

Abstract excerpt

Intrauterine growth restriction (IUGR) is caused by dysregulation of placental metabolism. Paternally inherited IUGR mutations in the fetus influence maternal physiology via the placenta. However, it is not known whether the maternal placenta also affects the extent of IUGR in such fetuses. In cattle and other ruminants, maternal-fetal communication occurs primarily at the placentomes. We previously identified a...

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Identifiers

PMID: 28679164
DOI: 10.1093/biolre/iox064

Genes

PEG3
SCRN3

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