Article

Spontaneous and ART-induced large offspring syndrome: similarities and differences in DNA methylome

2022-02-09

Abstract excerpt

Large/abnormal offspring syndrome (LOS/AOS) is a congenital overgrowth syndrome reported in ruminants produced by assisted reproduction (ART-LOS) which exhibit global disruption of the epigenome and transcriptome. LOS/AOS shares phenotypes and epigenotypes with the human congenital overgrowth condition Beckwith-Wiedemann syndrome. We have reported that LOS occurs spontaneously (SLOS), however, to date, no study ha...

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Literature Corpus work: 01b355f2-c944-5501-a9bc-fb4cb68beb89
DOI: 10.1101/2022.02.07.479430

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