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Article

MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2017

Bleuyard Jean-Yves, Fournier Marjorie, Nakato Ryuichiro, Couturier Anthony M, Katou Yuki, Ralf Christine, Hester Svenja S, Dominguez Daniel, Rhodes Daniela, Humphrey Timothy C, Shirahige Katsuhiko, Esashi Fumiko

Abstract excerpt

The partner and localiser of BRCA2 (PALB2) plays important roles in the maintenance of genome integrity and protection against cancer. Although PALB2 is commonly described as a repair factor recruited to sites of DNA breaks, recent studies provide evidence that PALB2 also associates with unperturbed chromatin. Here, we investigated the previously poorly described role of chromatin-associated PALB2 in undamaged...

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Share to BRCA2 Protein
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Replication

Share to Fanconi Anemia Complementation Group N Protein

Share to Histone-Lysine N-Methyltransferase

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Source

Open in PubMed Open full text

Identifiers

PMID: 28673974
DOI: 10.1073/pnas.1620208114
PMCID: PMC5530651

Genes

PALB2
SETD2
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.PMID 28673974Read ↗

MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.Semantic proximity Read ↗

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Mutation of cancer driver MLL2 results in transcription stress and genome instability.Semantic proximity Read ↗

Heterozygous mutations in PALB2 cause DNA replication and damage response defects.Semantic proximity Read ↗

DNA polymerase kappa stabilized by PTBP2 interacts with MRE11 and promotes genomic instability in leukemia cellsSemantic proximity Read ↗

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